Adversarial Training for Physics-Informed Neural Networks

Physics-informed neural networks have shown great promise in solving partial differential equations. However, due to insufficient robustness, vanilla PINNs often face challenges when solving complex PDEs, especially those involving multi-scale behaviors or solutions with sharp or oscillatory characteristics. To address these issues, based on the projected gradient descent adversarial attack, we proposed an adversarial training strategy for PINNs termed by AT-PINNs. AT-PINNs enhance the robustness of PINNs by fine-tuning the model with adversarial samples, which can accurately identify model failure locations and drive the model to focus on those regions during training. AT-PINNs can also perform inference with temporal causality by selecting the initial collocation points around temporal initial values. We implement AT-PINNs to the elliptic equation with multi-scale coefficients, Poisson equation with multi-peak solutions, Burgers equation with sharp solutions and the Allen-Cahn equation. The results demonstrate that AT-PINNs can effectively locate and reduce failure regions. Moreover, AT-PINNs are suitable for solving complex PDEs, since locating failure regions through adversarial attacks is independent of the size of failure regions or the complexity of the distribution

Re-initialization-free Level Set Method via Molecular Beam Epitaxy Equation Regularization for Image Segmentation

Variational level set method has become a powerful tool in image segmentation due to its ability to handle complex topological changes and maintain continuity and smoothness in the process of evolution. However its evolution process can be unstable, which results in over flatted or over sharpened contours and segmentation failure. To improve the accuracy and stability of evolution, we propose a high-order level set variational segmentation method integrated with molecular beam epitaxy (MBE) equation regularization. This method uses the crystal growth in the MBE process to limit the evolution of the level set function, and thus can avoid the re-initialization in the evolution process and regulate the smoothness of the segmented curve. It also works for noisy images with intensity inhomogeneity, which is a challenge in image segmentation. To solve the variational model, we derive the gradient flow and design scalar auxiliary variable (SAV) scheme coupled with fast Fourier transform (FFT), which can significantly improve the computational efficiency compared with the traditional semi-implicit and semi-explicit scheme. Numerical experiments show that the proposed method can generate smooth segmentation curves, retain fine segmentation targets and obtain robust segmentation results of small objects. Compared to existing level set methods, this model is state-of-the-art in both accuracy and efficiency

A Fractional-Order Telegraph Diffusion Model for Restoring Texture Images with Multiplicative Noise

Multiplicative noise removal from texture images poses a significant challenge. Different from the diffusion equation-based filter, we consider the telegraph diffusion equation-based model, which can effectively preserve fine structures and edges for texture images. The fractional-order derivative is imposed due to its textural detail enhancing capability. We also introduce the gray level indicator, which fully considers the gray level information of multiplicative noise images, so that the model can effectively remove high level noise and protect the details of the structure. The well-posedness of the proposed fractional-order telegraph diffusion model is presented by applying the Schauder’s fixed-point theorem. To solve the model, we develop an iterative algorithm based on the discrete Fourier transform in the frequency domain. We give various numerical results on despeckling natural and real SAR images. The experiments demonstrate that the proposed method can remove multiplicative noise and preserve texture well

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis. © 2010 Nature America, Inc. All rights reserved.0SCOPUS: ar.jinfo:eu-repo/semantics/publishe